Like keyboard events, you can also map joystick input to mouse actions.
Mouse events are more fragile than keyboard ones. While Enjoyble will work fine for most games, regular OS X (Cocoa) applications require specially formatted mouse events. Features such as click-and-drag or double-clicking will not work correctly, and so many applications will behave incorrectly if driven by an Enjoyable simulated mouse.
If you find a non-Cocoa application that has problems with Enjoyable's mouse support, please file a ticket in the issue tracker.